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Article

Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts.

Cellular signalling - 1 Apr 2007

Horowitz Jeffrey C, Rogers David S, Sharma Vishal, Vittal Ragini, White Eric S, Cui Zongbin, Thannickal Victor J

Abstract excerpt

Transforming growth factor-beta (TGF-beta) is a prototypical tumour-suppressor cytokine with cytostatic and pro-apoptotic effects on most target cells; however, mechanisms of its pro-survival/anti-apoptotic signalling in certain cell types and contexts remain unclear. In human lung fibroblasts, T...

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Source

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Identifiers

PMID: 17113264
DOI: 10.1016/j.cellsig.2006.10.001
PMCID: PMC1820832

Genes

SMAD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17113264-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts.PMID 17113264Read ↗

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