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Adenoviral Gene Transfer of Endothelin-1 in the Lung Induces Pulmonary Fibrosis through the Activation of Focal Adhesion Kinase

7 Sept 2012

Abstract excerpt

Endothelin-1 (ET-1) has been implicated in the development of pulmonary fibrosis, based on its capacity in vitro to promote extracellular matrix (ECM) production and contraction, and on studies showing elevated expression of ET-1 and its receptors in patients with pulmonary fibrosis. However, the in vivo fibrogenic effect of ET-1 is not well characterized. We used the adenoviral-mediated gene transfer of ET-1 to...

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Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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PMID: 22962065
DOI: 10.1165/rcmb.2011-0446oc

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