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Article

Foxa2 is required for the differentiation of pancreatic alpha-cells.

Developmental biology - 15 Feb 2005

Lee Catherine S, Sund Newman J, Behr Rüdiger, Herrera Pedro L, Kaestner Klaus H

Abstract excerpt

The differentiation of insulin-producing beta-cells has been investigated in great detail; however, little is known about the factors that delineate the second-most abundant endocrine lineage, the glucagon-producing alpha-cell. Here we utilize a novel YAC-based Foxa3Cre transgene to delete the winged helix transcription factor Foxa2 (formerly HNF-3beta) in the pancreatic primordium during midgestation. The...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15680365
DOI: 10.1016/j.ydbio.2004.10.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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