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Article

Foxa2 Controls Pdx1 Gene Expression in Pancreatic β-Cells In Vivo

1 Aug 2002

Abstract excerpt

Differentiation of early foregut endoderm into pancreatic endocrine and exocrine cells depends on a cascade of gene activation events controlled by various transcription factors. Prior in vitro analysis has suggested that the forkhead/winged helix transcription factor Foxa2 (formerly HNF-3beta) is a major upstream regulator of Pdx1, a homeobox gene essential for pancreatic development. Pdx1 is also essential for...

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Identifiers

PMID: 12145169
DOI: 10.2337/diabetes.51.8.2546

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Foxa2 Controls Pdx1 Gene Expression in Pancreatic β-Cells In VivoPMID 12145169Read ↗

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