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Article

Generation and characterization of recombinant influenza A (H1N1) viruses harboring amantadine resistance mutations.

Antimicrobial agents and chemotherapy - 1 Feb 2005

Abed Yacine, Goyette Nathalie, Boivin Guy

Abstract excerpt

The emergence of resistance to amantadine in influenza A viruses has been shown to occur rapidly during treatment as a result of single-amino-acid substitutions at position 26, 27, 30, 31, or 34 within the transmembrane domain of the matrix-(M)-2 protein. In this study, reverse genetics was used to generate and characterize recombinant influenza A (H1N1) viruses harboring L26F, V27A, A30T, S31N, G34E, and...

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Share to Amantadine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza A virus

Share to Influenza A Virus, H1N1 Subtype

Share to Mice, Inbred BALB C

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Source

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Identifiers

PMID: 15673732
DOI: 10.1128/AAC.49.2.556-559.2005
PMCID: PMC547263

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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