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Article

[Rapid method of producing influenza A virus variants resistant to amantadine and remantadine and their primary characteristics].

Voprosy virusologii - 1 Jan 2000

Vladyko A S, Shobukhov V M, Linitskaia G L, Galegov G A

Abstract excerpt

A rapid method for production of influenza A virus variants resistant to the adamantane series derivatives, amantadine and remantadine, has been developed. The method consisted of two stages. In the first, the virus was subjected to one passage in the presence of the preparations under a liquid overlayer in a one-cycle experiment. In the second stage, the resulting virus was titrated by the plaque method, the...

Topics

Adamantane
Amantadine
Drug Resistance, Microbial
Genetic Variation
Influenza A virus
Rimantadine
Viral Plaque Assay
Virus Cultivation
Virus Replication

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7135921

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7135921-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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