Article
High frequency of amantadine-resistant influenza A (H3N2) viruses in the 2005-2006 season and rapid detection of amantadine-resistant influenza A (H3N2) viruses by MAMA-PCR.
Japanese journal of infectious diseases - 1 Jul 2007
Hata Mami, Tsuzuki Masako, Goto Yasuhiro, Kumagai Norimichi, Harada Miki, Hashimoto Michiko, Tanaka Seidai, Sakae Kenji, Kimura Takashi, Minagawa Hiroko, Miyazaki Yutaka
Abstract excerpt
Using the newly designed mismatch amplification mutation assay (MAMA) PCR, we demonstrated the high frequency of amantadine-resistant influenza A (H3N2) viruses isolated during the 2005-2006 season by detecting the mutation at amino acid position 31 of the M2 protein (S31N). Further, phylogenetic analyses of the HA1 sequences of the S31N viruses revealed that they comprised a clonal lineage that would result in...
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