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Article

Adamantane-resistant influenza a viruses in the world (1902-2013): frequency and distribution of M2 gene mutations.

PloS one - 1 Jan 2015

Dong Guoying, Peng Chao, Luo Jing, Wang Chengmin, Han Le, Wu Bin, Ji Guangju, He Hongxuan

Abstract excerpt

Adamantanes (amantadine and rimantadine) have been used to prevent and treat influenza A virus infections for many years; however, resistance to these drugs has been widely reported in the world. To investigate the frequency and distribution of M2 gene mutations in adamantane-resistant influenza variants circulated in the world between 1902 and 2013, 31251 available M2 protein sequences from different HA-subtype...

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Identifiers

PMID: 25768797
DOI: 10.1371/journal.pone.0119115
PMCID: PMC4358984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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