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Article

Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage.

The Journal of biological chemistry - 15 Apr 2005

Ohashi Akihiro, Zdzienicka Malgorzata Z, Chen Junjie, Couch Fergus J

Abstract excerpt

The BRCA2 breast cancer tumor suppressor is involved in the repair of double strand breaks and broken replication forks by homologous recombination through its interaction with DNA repair protein Rad51. Cells defective in BRCA2.FANCD1 are extremely sensitive to mitomycin C (MMC) similarly to cells deficient in any of the Fanconi anemia (FA) complementation group proteins (FANC). These observations suggest that...

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Source

Identifiers

PMID: 15671039
DOI: 10.1074/jbc.M414669200

Genes

BRCA2
FANCD2
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage.PMID 15671039Read ↗

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C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair.Semantic proximity Read ↗

Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand crosslinksSemantic proximity Read ↗

Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif.Semantic proximity Read ↗

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