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Article

Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways

28 Apr 2004

Abstract excerpt

Fanconi anaemia (FA) is a chromosomal instability disorder characterized by cellular sensitivity to DNA interstrand crosslinking agents and a high risk of cancer. Six of the eight proteins encoded by the known FA genes form a nuclear complex which is required for the monoubiquitination of the FANCD2 protein. FANCD2 complexes and colocalizes with BRCA1, but its presumptive role in DNA repair has not yet been...

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PMID: 15115758
DOI: 10.1093/hmg/ddh135

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