Article
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
Journal of the National Cancer Institute - 2 Mar 2011
Fletcher Olivia, Johnson Nichola, Orr Nick, Hosking Fay J, Gibson Lorna J, Walker Kate, Zelenika Diana, Gut Ivo, Heath Simon, Palles Claire, Coupland Ben, Broderick Peter, Schoemaker Minouk, Jones Michael, Williamson Jill, Chilcott-Burns Sarah, Tomczyk Katarzyna, Simpson Gemma, Jacobs Kevin B, Chanock Stephen J, Hunter David J, Tomlinson Ian P, Swerdlow Anthony, Ashworth Alan, Ross Gillian, dos Santos Silva Isabel, Lathrop Mark, Houlston Richard S, Peto Julian
Abstract excerpt
BACKGROUND: Genome-wide association studies have identified several common genetic variants associated with breast cancer risk. It is likely, however, that a substantial proportion of such loci have not yet been discovered. METHODS: We compared 296,114 tagging single-nucleotide polymorphisms in 1694 breast cancer case subjects (92% with two primary cancers or at least two affected first-degree relatives) and 2365...
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