Article
Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.
Proceedings of the National Academy of Sciences of the United States of America - 18 Mar 2008
Gold Bert, Kirchhoff Tomas, Stefanov Stefan, Lautenberger James, Viale Agnes, Garber Judy, Friedman Eitan, Narod Steven, Olshen Adam B, Gregersen Peter, Kosarin Kristi, Olsh Adam, Bergeron Julie, Ellis Nathan A, Klein Robert J, Clark Andrew G, Norton Larry, Dean Michael, Boyd Jeff, Offit Kenneth
Abstract excerpt
We performed a three-phase genome-wide association study (GWAS) using cases and controls from a genetically isolated population, Ashkenazi Jews (AJ), to identify loci associated with breast cancer risk. In the first phase, we compared allele frequencies of 150,080 SNPs in 249 high-risk, BRCA1/2 mutation-negative AJ familial cases and 299 cancer-free AJ controls using chi(2) and the Cochran-Armitage trend tests....
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