Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A polymorphism in the TNF-alpha promoter gene is associated with pediatric onset and colonic location of Crohn's disease.

The American journal of gastroenterology - 1 Feb 2005

Levine Arie, Karban Amir, Eliakim Rami, Shaoul Ron, Reif Shimon, Pacht Avi, Wardi Joram, Yakir Benjamin, Silver Esther Leshinsky

Abstract excerpt

OBJECTIVES: Studies suggest that pediatric onset of Crohn's disease (CD) may demonstrate more frequent upper intestinal and colonic location and in male gender, in comparison to adults. Variability in age of onset (AOO) and location of disease have not been adequately explained to date. NOD2/CARD15 is highly expressed in the ileum, while TNF-alpha expression is distributed throughout the gastrointestinal tract....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crohn Disease

Share to Genetic Predisposition to Disease

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 15667501
DOI: 10.1111/j.1572-0241.2005.41126.x

Genes

TNF
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A polymorphism in the TNF-alpha promoter gene is associated with pediatric onset and colonic location of Crohn's disease.PMID 15667501Read ↗

Pediatric onset Crohn's colitis is characterized by genotype-dependent age-related susceptibility.Semantic proximity Read ↗

Is age of onset of Crohn's disease governed by mutations in NOD2/caspase recruitment domains 15 and Toll-like receptor 4? Evaluation of a pediatric cohort.Semantic proximity Read ↗

TNF promoter polymorphisms and modulation of growth retardation and disease severity in pediatric Crohn's disease.Semantic proximity Read ↗

Genetic determinants associated with early age of diagnosis of IBD.Semantic proximity Read ↗

NOD2/CARD15 and TNFA, but not IL1B and IL1RN, are associated with Crohn's disease.Semantic proximity Read ↗

Associations between NOD2/CARD15 genotype and phenotype in Crohn's disease--Are we there yet?Semantic proximity Read ↗

Disease behavior in children with Crohn's disease: the effect of disease duration, ethnicity, genotype, and phenotype.Semantic proximity Read ↗

CARD15 gene mutations and risk for early surgery in pediatric-onset Crohn's disease.Semantic proximity Read ↗

The molecular classification of the clinical manifestations of Crohn's disease.Semantic proximity Read ↗

Genotype-phenotype analysis in childhood-onset Crohn's disease: NOD2/CARD15 variants consistently predict phenotypic characteristics of severe disease.Semantic proximity Read ↗

Genetic susceptibility has a more important role in pediatric-onset Crohn's disease than in adult-onset Crohn's disease.Semantic proximity Read ↗

Functional interaction of CARD15/NOD2 and Crohn's disease-associated TNFalpha polymorphisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.