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Article

Is age of onset of Crohn's disease governed by mutations in NOD2/caspase recruitment domains 15 and Toll-like receptor 4? Evaluation of a pediatric cohort.

Pediatric research - 1 Sept 2005

Leshinsky-Silver Esther, Karban Amir, Buzhakor Erena, Fridlander Marcelo, Yakir Benjamin, Eliakim Rami, Reif Shimon, Shaul Roni, Boaz Mona, Lev Dorit, Levine Arie

Abstract excerpt

Crohn's disease (CD) is caused by a combination of environmental and genetic factors. It is not clear at present whether age of onset (AOO) is a random event or dictated by genotype or environmental factors. Mutations in the NOD2/caspase recruitment domains 15 (CARD15) and in the Toll-like receptor 4 (TLR4) gene have been associated with increased susceptibility for CD. We sought to determine whether single or...

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Identifiers

PMID: 16148063
DOI: 10.1203/01.PDR.0000175640.75468.D6

Genes

NOD2
TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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