Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TNF promoter polymorphisms and modulation of growth retardation and disease severity in pediatric Crohn's disease.

The American journal of gastroenterology - 1 Jul 2005

Levine Arie, Shamir Raanan, Wine Eytan, Weiss Batya, Karban Amir, Shaoul Ron R, Reif Shimon S, Yakir Benjamin, Friedlander Marcello, Kaniel Yael, Leshinsky-Silver Esther

Abstract excerpt

OBJECTIVES: Delayed growth is common in pediatric Crohn's disease (CD). Multiple factors have been shown to affect growth in this situation, the most prominent being the presence and severity of inflammation and inadequate nutritional intake. Inflammation, anorexia, and weight loss are all manifestations of circulating TNF-alpha, which is elevated in CD. The ability to secrete TNF-alpha may be affected by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenine
Share to Crohn Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytosine

Share to Growth Disorders

Share to Guanine

Share to Severity of Illness Index

Share to Thymine

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 15984988
DOI: 10.1111/j.1572-0241.2005.41737.x

Genes

TNF
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TNF promoter polymorphisms and modulation of growth retardation and disease severity in pediatric Crohn's disease.PMID 15984988Read ↗

Pediatric Crohn's disease and growth retardation: the role of genotype, phenotype, and disease severity.Semantic proximity Read ↗

A polymorphism in the TNF-alpha promoter gene is associated with pediatric onset and colonic location of Crohn's disease.Semantic proximity Read ↗

Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.Semantic proximity Read ↗

Cytokine Tumor Necrosis Factor‐alpha A Promoter Gene Polymorphism at Position −308 G→A and Pediatric Inflammatory Bowel DiseaseSemantic proximity Read ↗

Disease behavior in children with Crohn's disease: the effect of disease duration, ethnicity, genotype, and phenotype.Semantic proximity Read ↗

Age-of-onset-dependent influence of NOD2 gene variants on disease behaviour and treatment in Crohn's disease.Semantic proximity Read ↗

Polymorphisms of tumor necrosis factor-alpha but not MDR1 influence response to medical therapy in pediatric-onset inflammatory bowel disease.Semantic proximity Read ↗

Interleukin 10 (IL-10) gene variants and susceptibility for paediatric onset Crohn's disease.Semantic proximity Read ↗

Genetic Determinants of Pediatric Inflammatory Bowel Disease: Is Age of Onset Genetically Determined?Semantic proximity Read ↗

Is age of onset of Crohn's disease governed by mutations in NOD2/caspase recruitment domains 15 and Toll-like receptor 4? Evaluation of a pediatric cohort.Semantic proximity Read ↗

TNFα and IL10 SNPs act together to predict disease behaviour in Crohn’s diseaseSemantic proximity Read ↗

Serum C-reactive protein and CRP genotype in pediatric inflammatory bowel disease: influence on phenotype, natural history, and response to therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.