Article
The molecular classification of the clinical manifestations of Crohn's disease.
Gastroenterology - 1 Apr 2002
Ahmad Tariq, Armuzzi Alessandro, Bunce Mike, Mulcahy-Hawes Kim, Marshall Sara E, Orchard Timothy R, Crawshaw Jonathan, Large Oliver, de Silva Arjuna, Cook Julia T, Barnardo Martin, Cullen Sue, Welsh Ken I, Jewell Derek P
Abstract excerpt
BACKGROUND & AIMS: Crohn's disease is a common inflammatory disorder of the gut characterized by variation in both location and behavior. Chromosome 16 and the HLA region on chromosome 6 have been implicated in susceptibility to disease. Mutations in the NOD2/CARD15 gene, recently identified on chromosome 16, have been associated with disease overall but are found in only 25% of patients. No data regarding their...
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