Article
Genotype-phenotype analysis in childhood-onset Crohn's disease: NOD2/CARD15 variants consistently predict phenotypic characteristics of severe disease.
Inflammatory bowel diseases - 1 Nov 2005
Russell Richard K, Drummond Hazel E, Nimmo Elaine E, Anderson Niall, Smith Linda, Wilson David C, Gillett Peter M, McGrogan Paraic, Hassan Kamal, Weaver Lawrence T, Bisset Michael, Mahdi Gamal, Satsangi Jack
Abstract excerpt
INTRODUCTION: The incidence of early-onset CD in Scotland is among the highest worldwide. Three single nucleotide polymorphisms (SNPs) R702W, G908R and Leu1007finsC in the NOD2/CARD15 gene predispose to adult CD. We investigated the contribution of these variants to disease susceptibility and phenotype in the Scottish early-onset IBD population. PATIENTS AND METHODS: 906 individuals including 247 Scottish IBD...
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