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Article

CARD15 gene mutations and risk for early surgery in pediatric-onset Crohn's disease.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Nov 2004

Kugathasan Subra, Collins Nicole, Maresso Karen, Hoffmann Raymond G, Stephens Michael, Werlin Steven L, Rudolph Colin, Broeckel Ulrich

Abstract excerpt

BACKGROUND & AIMS: The risk for Crohn's disease (CD) is determined in part by genetic factors. Three recently described mutations in the CARD15(NOD2) gene have been associated with adult-onset CD. We investigated the effect of CARD15 mutations on disease manifestation, disease progression, and the risk for early surgery in childhood-onset CD. METHODS: Genotyping for 3 CARD15 mutations: R702W, G908R, and 3020insC,...

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Source

Identifiers

PMID: 15551253
DOI: 10.1016/s1542-3565(04)00452-5

Genes

NOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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