A single point mutation of the influenza C virus glycoprotein (HEF) changes the viral receptor-binding activity.

doi:10.1016/0042-6822(92)90737-a

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Article

A single point mutation of the influenza C virus glycoprotein (HEF) changes the viral receptor-binding activity.

Virology - 1 May 1992

Szepanski S, Gross H J, Brossmer R, Klenk H D, Herrler G

Abstract excerpt

From strain JHB/1/66 of influenza C virus a mutant was derived with a change in the cell tropism. The mutant was able to grow in a subline of Madin-Darby canine kidney cells (MDCK II) which is resistant to infection by the parent virus due to a lack of receptors. Inactivation of cellular receptor...

Topics

Amino Acid Sequence
Animals
Cell Line
Dogs
Hemagglutinin Glycoproteins, Influenza Virus
Hemagglutinins, Viral
Gammainfluenzavirus
Kinetics
Molecular Sequence Data
Mutation
Receptors, Virus
Viral Envelope Proteins

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