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Article

Hemagglutinin variants of influenza A(H1N1)pdm09 virus with reduced affinity for sialic acid receptors.

Archives of virology - 1 May 2014

Ayora-Talavera G, Cetina-Montejo L, Matos-Patrón A, Romero-Beltrán L

Abstract excerpt

In influenza A H1 virus, amino acids at position 190 and 225 of HA affect replication and transmission. In this study, we show that the mutation D190Y in the HA of influenza AH1N1pdm09 virus reduces the affinity of the virus for sialic acid receptors expressed at the surface of red blood cells from different species without affecting virus replication in MDCK cells.

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Share to Gene Expression Regulation, Viral
Share to Hemagglutinins
Share to Influenza A Virus, H1N1 Subtype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Cell Surface

Share to Sialic Acids

Source

Identifiers

PMID: 24297491
DOI: 10.1007/s00705-013-1934-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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