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Article

Analysis of influenza virus hemagglutinin receptor binding mutants with limited receptor recognition properties and conditional replication characteristics.

Journal of virology - 1 Dec 2011

Bradley Konrad C, Galloway Summer E, Lasanajak Yi, Song Xuezheng, Heimburg-Molinaro Jamie, Yu Hai, Chen Xi, Talekar Ganesh R, Smith David F, Cummings Richard D, Steinhauer David A

Abstract excerpt

To examine the range of selective processes that potentially operate when poorly binding influenza viruses adapt to replicate more efficiently in alternative environments, we passaged a virus containing an attenuating mutation in the hemagglutinin (HA) receptor binding site in mice and characterized the resulting mutants with respect to the structural locations of mutations selected, the replication phenotypes of...

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Identifiers

PMID: 21917953
DOI: 10.1128/JVI.05570-11
PMCID: PMC3209400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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