Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity.

doi:10.1038/304076a0

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Article

Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity.

Nature - 1 Jan 2000

Rogers G N, Paulson J C, Daniels R S, Skehel J J, Wilson I A, Wiley D C

Abstract excerpt

The haemagglutinin (HA) glycoproteins of influenza virus membranes are responsible for binding viruses to cells by interacting with membrane receptor molecules which contain sialic acid (for review see ref. 1). This interaction is known to vary in detailed specificity for different influenza viru...

Topics

Amino Acid Sequence
Amino Acids
Animals
Cell Line
Dogs
Epitopes
Genetic Variation
Hemagglutinins
Influenza A virus
Kidney
Models, Molecular
Protein Conformation
Receptors, Immunologic
Structure-Activity Relationship

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