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Article

Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity.

Nature - 1 Jan 2000

Rogers G N, Paulson J C, Daniels R S, Skehel J J, Wilson I A, Wiley D C

Abstract excerpt

The haemagglutinin (HA) glycoproteins of influenza virus membranes are responsible for binding viruses to cells by interacting with membrane receptor molecules which contain sialic acid (for review see ref. 1). This interaction is known to vary in detailed specificity for different influenza viruses (see, for example, refs 2-4) and we have attempted to identify the sialic acid binding site of the haemagglutinin...

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PMID: 6191220
DOI: 10.1038/304076a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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