Article
Adaptation of influenza A viruses to cells expressing low levels of sialic acid leads to loss of neuraminidase activity.
Journal of virology - 1 Apr 2001
Hughes M T, McGregor M, Suzuki T, Suzuki Y, Kawaoka Y
Abstract excerpt
Influenza A viruses possess two virion surface proteins, hemagglutinin (HA) and neuraminidase (NA). The HA binds to sialyloligosaccharide viral receptors, while the NA removes sialic acids from the host cell and viral sialyloligosaccarides. Alterations of the HA occur during adaptation of influenza viruses to new host species, as in the 1957 and 1968 influenza pandemics. To gain a better understanding of the...
Topics
- Adaptation, Physiological
- Animals
- Base Sequence
- Cell Line
- Chick Embryo
- Chromatography, High Pressure Liquid
- Dogs
- Fluorometry
- Hemagglutinin Glycoproteins, Influenza Virus
- Humans
- Influenza A virus
- Lectins
- Mutation
- N-Acetylneuraminic Acid