Single amino acid substitutions in the hemagglutinin can alter the host range and receptor binding properties of H1 strains of influenza A virus.

doi:10.1128/JVI.65.6.3022-3028.1991

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Article

Single amino acid substitutions in the hemagglutinin can alter the host range and receptor binding properties of H1 strains of influenza A virus.

Journal of virology - 1 Jun 1991

Aytay S, Schulze I T

Abstract excerpt

We have previously characterized an influenza A (H1N1) virus which has host-dependent growth and receptor binding properties and have shown that a mutation which removes an oligosaccharide from the tip of the hemagglutinin (HA) by changing Asn-129 to Asp permits this virus to grow to high titer i...

Topics

Amino Acids
Animals
Antibodies, Monoclonal
Carbohydrate Conformation
Cells, Cultured
Galactose
Glycosylation
Hemagglutinin Glycoproteins, Influenza Virus
Hemagglutinins, Viral
Influenza A virus
Mutation
N-Acetylneuraminic Acid
Protein Conformation
Receptors, Virus
Sialic Acids
Viral Envelope Proteins

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Identifiers

PMID: 2033664
DOI: 10.1128/JVI.65.6.3022-3028.1991
PMCID: PMC240956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2033664-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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