Article
Replication of DHBV genomes with mutations at the sites of initiation of minus- and plus-strand DNA synthesis.
Virology - 1 May 1992
Condreay L D, Wu T T, Aldrich C E, Delaney M A, Summers J, Seeger C, Mason W S
Abstract excerpt
We have examined the consequences on duck hepatitis B virus DNA synthesis of deleting the 5' and 3' copies of the 12 base sequence, DR1, from the viral pregenome. With the wild-type virus, reverse transcription initiates at nt 2537 within the 3' copy of DR1. When this sequence was deleted, initiation of reverse transcription was found at two other sites located closer to the 3' end of the pregenome (nt 2576 and...
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