Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synthesis of hepadnavirus particles that contain replication-defective duck hepatitis B virus genomes in cultured HuH7 cells.

Journal of virology - 1 Feb 1990

Horwich A L, Furtak K, Pugh J, Summers J

Abstract excerpt

To evaluate the possibility of producing transducible replication-defective hepadnaviruses, cloned mutant duck hepatitis B virus genomes were tested both for virus antigen production and viral DNA synthesis following transfection into the human hepatoma cell line HuH7. Deletion of a cis-acting 12-nucleotide sequence implicated in viral DNA synthesis, direct repeat 1 (DR1), resulted in the loss of ability to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Cells, Cultured
Share to DNA Replication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Viral

Share to Mutation

Share to Transfection

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 2153230
DOI: 10.1128/JVI.64.2.642-650.1990
PMCID: PMC249155

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synthesis of hepadnavirus particles that contain replication-defective duck hepatitis B virus genomes in cultured HuH7 cells.PMID 2153230Read ↗

Construction of avian hepadnavirus variants with enhanced replication and cytopathicity in primary hepatocytesSemantic proximity Read ↗

Pregenomic RNA Launch Hepatitis B Virus Replication System Facilitates the Mechanistic Study of Antiviral Agents and Drug-Resistant Variants on Covalently Closed Circular DNA SynthesisSemantic proximity Read ↗

Defective replication units of hepatitis B virus.Semantic proximity Read ↗

Naturally Occurring Hepatitis C Virus Subgenomic Deletion Mutants Replicate Efficiently in Huh-7 Cells and Are trans -Packaged In Vitro To Generate Infectious Defective ParticlesSemantic proximity Read ↗

Replication of DHBV genomes with mutations at the sites of initiation of minus- and plus-strand DNA synthesis.Semantic proximity Read ↗

Characterization of hepatitis B virus core mutants that inhibit viral replication.Semantic proximity Read ↗

Rescue of a segmented negative-strand RNA virus entirely from cloned complementary DNAsSemantic proximity Read ↗

Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification.Semantic proximity Read ↗

trans-dominant inhibition of human hepatitis delta virus genome replication.Semantic proximity Read ↗

Capsid coding sequence is required for efficient replication of human rhinovirus 14 RNASemantic proximity Read ↗

Launching the yeast 23S RNA Narnavirus shows 5' and 3' cis-acting signals for replication.Semantic proximity Read ↗

Persistent and Transient Replication of Full-Length Hepatitis C Virus Genomes in Cell CultureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.