Article
Circularization of an RNA template via long-range base pairing is critical for hepadnaviral reverse transcription.
Virology - 20 Feb 2008
Shin Myeong-Kyun, Kim Jong-Hoon, Ryu Dong-Kyun, Ryu Wang-Shick
Abstract excerpt
Although an overall genetic strategy for hepadnaviral reverse transcription has been established, the mechanism that underlies the minus-strand transfer is still poorly defined. We and others independently identified a novel cis-acting element, termed beta or varphi, respectively, that is critical for the minus-strand DNA synthesis of hepatitis B virus. A 5'-3', long-range interaction of the RNA template was...
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