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Article

Specific hepatitis B virus minus-strand DNA synthesis requires only the 5' encapsidation signal and the 3'-proximal direct repeat DR1

1 Jan 1996

Abstract excerpt

Human hepatitis B virus (HBV) is a small DNA virus that replicates inside the viral nucleocapsid by reverse transcription of an RNA intermediate, the pregenome. The sequences encompassing the encapsidation signal epsilon and the direct repeat DR1 are present in two copies of this terminally redundant transcript. We have recently shown that HBV minus-strand DNA synthesis involves transfer of a short DNA primer...

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Identifiers

PMID: 8523575
DOI: 10.1128/jvi.70.1.585-589.1996

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Related research

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Research trail→

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Specific hepatitis B virus minus-strand DNA synthesis requires only the 5' encapsidation signal and the 3'-proximal direct repeat DR1PMID 8523575Read ↗

A bulged region of the hepatitis B virus RNA encapsidation signal contains the replication origin for discontinuous first-strand DNA synthesisSemantic proximity Read ↗

A pregenomic RNA sequence adjacent to DR1 and complementary to epsilon influences hepatitis B virus replication efficiency.Semantic proximity Read ↗

Base Pairing between the 5′ Half of ε and a <i>cis</i> -Acting Sequence, Φ, Makes a Contribution to the Synthesis of Minus-Strand DNA for Human Hepatitis B VirusSemantic proximity Read ↗

Hepadnavirus reverse transcription initiates within the stem-loop of the RNA packaging signal and employs a novel strand transfer.Semantic proximity Read ↗

RNA sequences controlling the initiation and transfer of duck hepatitis B virus minus-strand DNA.Semantic proximity Read ↗

Complementarity between epsilon and phi sequences in pregenomic RNA influences hepatitis B virus replication efficiency.Semantic proximity Read ↗

Mutations in the epsilon sequences of human hepatitis B virus affect both RNA encapsidation and reverse transcription.Semantic proximity Read ↗

A short cis-acting sequence is required for hepatitis B virus pregenome encapsidation and sufficient for packaging of foreign RNA.Semantic proximity Read ↗

Asymmetric Modification of Hepatitis B Virus (HBV) Genomes by an Endogenous Cytidine Deaminase inside HBV Cores Informs a Model of Reverse Transcription.Semantic proximity Read ↗

Sequence- and structure-specific determinants in the interaction between the RNA encapsidation signal and reverse transcriptase of avian hepatitis B viruses.Semantic proximity Read ↗

Circularization of an RNA template via long-range base pairing is critical for hepadnaviral reverse transcription.Semantic proximity Read ↗

Replication of DHBV genomes with mutations at the sites of initiation of minus- and plus-strand DNA synthesis.Semantic proximity Read ↗

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