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Article

Effectiveness of extreme discordant sib pairs to detect oligogenic disease loci.

Genetic epidemiology - 1 Jan 1997

Rogus J J, Harrington D P, Jorgenson E, Xu X

Abstract excerpt

A method for the genomic screening of quantitative traits using extreme discordant sib pairs (EDSPs) has recently been described by Risch and Zhang [1995; 1996]. For many models relevant to common, genetically complex diseases, EDSPs are the most powerful siblings for detecting linkage. Thus, if such siblings can be identified and collected, powerful studies with reasonable genotyping budgets can be conducted....

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Identifiers

PMID: 9433594
DOI: 10.1002/(SICI)1098-2272(1997)14:6<879::AID-GEPI53>3.0.CO;2-J

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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