Article
Haptoglobin genotype and its role in determining heme-iron mediated vascular disease.
Pharmacological research - 1 Jul 2012
Goldenstein Hagit, Levy Nina S, Levy Andrew P
Abstract excerpt
Haptoglobin (Hp) is a hemoglobin (Hb) binding protein whose major function is to prevent heme-iron mediated oxidation. The polymorphic nature of the Hp gene results in varying levels of antioxidant function associated with the protein products. Multiple clinical studies have now determined that the Hp 2-2 genotype is associated with an increased risk of developing vascular complications in patients suffering from...
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