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Article

Genetically determined heterogeneity in hemoglobin scavenging and susceptibility to diabetic cardiovascular disease.

Circulation research - 13 Jun 2003

Asleh Rabea, Marsh Stuart, Shilkrut Mark, Binah Ofer, Guetta Julia, Lejbkowicz Flavio, Enav Ben, Shehadeh Naim, Kanter Yoram, Lache Orit, Cohen Osher, Levy Nina S, Levy Andrew P

Abstract excerpt

A major function of haptoglobin (Hp) is to bind hemoglobin (Hb) to form a stable Hp-Hb complex and thereby prevent Hb-induced oxidative tissue damage. Clearance of the Hp-Hb complex can be mediated by the monocyte/macrophage scavenger receptor CD163. We recently demonstrated that diabetic individuals homozygous for the Hp 2 allele (Hp 2-2) were at 500% greater risk of cardiovascular disease (CVD) compared with...

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Share to Antigens, Differentiation, Myelomonocytic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12750308
DOI: 10.1161/01.RES.0000076889.23082.F1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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