Article
Vitamin E therapy results in a reduction in HDL function in individuals with diabetes and the haptoglobin 2-1 genotype.
Atherosclerosis - 1 Nov 2011
Farbstein Dan, Blum Shany, Pollak Mordechai, Asaf Roy, Viener Hilla Lee, Lache Orit, Asleh Rabea, Miller-Lotan Rachel, Barkay Ido, Star Michael, Schwartz Avery, Kalet-Littman Shiri, Ozeri David, Vaya Jacob, Tavori Hagai, Vardi Moshe, Laor Arie, Bucher Stephen E, Anbinder Yefim, Moskovich Doron, Abbas Nur, Perry Netta, Levy Yishai, Levy Andrew P
Abstract excerpt
OBJECTIVE: Vitamin E provides cardiovascular protection to individuals with diabetes and the haptoglobin 2-2 genotype but appears to increase cardiovascular risk in individuals with diabetes and the haptoglobin 2-1 genotype. We have previously demonstrated that the haptoglobin protein is associated with HDL and that HDL function and its oxidative modification are haptoglobin genotype dependent. We set out to test...
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