Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of mutating the two cysteines required for HBe antigenicity on hepatitis B virus DNA replication and virion secretion.

Virology - 5 Feb 2005

Bang Genie, Kim Kyun-Hwan, Guarnieri Michael, Zoulim Fabien, Kawai Shigenobu, Li Jisu, Wands Jack, Tong Shuping

Abstract excerpt

Hepatitis B virus (HBV) variants with impaired expression of e antigen (HBeAg) frequently arise at the chronic stage of infection, as exemplified by precore and core promoter mutants. Since an intramolecular disulfide bond maintains the secondary structure of HBeAg, we explored effect of missense mutations of either cysteine codon. Consistent with earlier reports, substitution of each cysteine rendered HBeAg...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon
Share to Cysteine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Replication

Share to Hepatitis B Surface Antigens

Share to Hepatitis B virus

Share to Viral Core Proteins

Share to Virion

Share to Virus Replication

Source

Identifiers

PMID: 15661154
DOI: 10.1016/j.virol.2004.11.029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of mutating the two cysteines required for HBe antigenicity on hepatitis B virus DNA replication and virion secretion.PMID 15661154Read ↗

Hepatitis B Virus e Antigen VariantsSemantic proximity Read ↗

Critical role of the 36-nucleotide insertion in hepatitis B virus genotype G in core protein expression, genome replication, and virion secretion.Semantic proximity Read ↗

Core protein mutations are key determinants of hepatitis B virus replication during the hepatitis B e antigen-negative stage.Semantic proximity Read ↗

Novel mutation in Hepatitis B virus preventing HBeAg production and resembling primate strains.Semantic proximity Read ↗

Replication capacities of natural and artificial precore stop codon mutants of hepatitis B virus: relevance of pregenome encapsidation signal.Semantic proximity Read ↗

Conserved Lysine Residues of Hepatitis B Virus Core Protein Are Not Required for Covalently Closed Circular DNA Formation.Semantic proximity Read ↗

Stability governs the apparent expression of "particulate" hepatitis B e antigen by mutant hepatitis B virus core particles.Semantic proximity Read ↗

Sequence variation upstream of precore translation initiation codon reduces hepatitis B virus e antigen production.Semantic proximity Read ↗

Virion Secretion of Hepatitis B Virus Naturally Occurring Core Antigen Variants.Semantic proximity Read ↗

Impaired virion secretion by hepatitis B virus immune escape mutants and its rescue by wild-type envelope proteins or a second-site mutation.Semantic proximity Read ↗

Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigenSemantic proximity Read ↗

Major HBV splice variant encoding a novel protein important for infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.