Article
Primary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis
17 Jan 2005
Abstract excerpt
Hemophagocytic syndrome (HS) is a severe and often fatal syndrome resulting from potent and uncontrolled activation and proliferation of T-lymphocytes, leading to excessive macrophage activation and multiple deleterious effects. The onset of HS characterizes several inherited disorders in humans. In each condition, the molecular defect impairs the granule-dependent cytotoxic activity of lymphocytes, thus...
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