Article
Inherited defects in lymphocyte cytotoxic activity.
Immunological reviews - 1 May 2010
Pachlopnik Schmid Jana, Schmid Jana P, Côte Marjorie, Ménager Mickaël M, Burgess Agathe, Nehme Nadine, Ménasché Gaël, Fischer Alain, de Saint Basile Geneviève
Abstract excerpt
The granule-dependent cytotoxic activity of lymphocytes plays a critical role in the defense against virally infected cells and tumor cells. The importance of this cytotoxic pathway in immune regulation is evidenced by the severe and often fatal condition, known as hemophagocytic lymphohistiocytic syndrome (HLH) that occurs in mice and humans with genetically determined impaired lymphocyte cytotoxic function. HLH...
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