Article
The hyperinflammatory spectrum: from defects in cytotoxicity to cytokine control
28 Apr 2023
Abstract excerpt
Cytotoxic lymphocytes kill target cells through polarized release of the content of cytotoxic granules towards the target cell. The importance of this cytotoxic pathway in immune regulation is evidenced by the severe and often fatal condition, known as hemophagocytic lymphohistiocytosis (HLH) that occurs in mice and humans with inborn errors of lymphocyte cytotoxic function. The clinical and preclinical data...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.