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Article

Hemophagocytic lymphohistiocytosis (HLH) and related disorders.

Hematology. American Society of Hematology. Education Program - 1 Jan 2009

Filipovich Alexandra H

Abstract excerpt

Hemophagocytic lymphohistiocytosis (HLH), which has many genetic causes, is characterized by multi-system inflammation. HLH is a reactive process resulting from prolonged and excessive activation of antigen presenting cells (macrophages, histiocytes) and CD8(+) T cells. Hemophagocytosis, which is mediated through the CD163 heme-scavenging receptor, is a hallmark of activated macrophages/histiocytes and is the...

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Identifiers

PMID: 20008190
DOI: 10.1182/asheducation-2009.1.127

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