Article

Cytotoxic granule secretion by lymphocytes and its link to immune homeostasis

2015-09-30

Abstract excerpt

The granule-dependent cytotoxic activity of T and natural killer lymphocytes has progressively emerged as an important effector pathway not only for host defence but also for immune regulation. The analysis of an early-onset, severe, primary immune dysregulatory syndrome known as hemophagocytic lymphohistiocytosis (HLH) has been decisive in highlighting this latter role and identifying key effectors on the basis o...

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Literature Corpus work: 1c368fec-2f71-5f16-a40e-516ae4f58539
DOI: 10.12688/f1000research.6754.1

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