Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Advances in the pathogenesis of primary and secondary haemophagocytic lymphohistiocytosis: differences and similarities.

British journal of haematology - 1 Jul 2016

Brisse Ellen, Wouters Carine H, Matthys Patrick

Abstract excerpt

Haemophagocytic lymphohistiocytosis (HLH) comprises a heterogeneous spectrum of hyperinflammatory conditions that are inherited (primary HLH) or acquired in a context of infections, malignancies or autoimmune/autoinflammatory disorders (secondary HLH). Genetic defects in the cytotoxic machinery of natural killer and CD8(+) T cells underlie primary HLH, with residual cytotoxicity determining disease severity....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune and Inflammatory Disorders Research
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diagnosis, Differential

Share to Inflammation

Share to Lymphohistiocytosis, Hemophagocytic

Share to Mutation

Share to Natural Killer T-Cells

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 27264204
DOI: 10.1111/bjh.14147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Advances in the pathogenesis of primary and secondary haemophagocytic lymphohistiocytosis: differences and similarities.PMID 27264204Read ↗

Pathophysiology and epidemiology of hemophagocytic lymphohistiocytosis.Semantic proximity Read ↗

Pathogenesis of Hemophagocytic Lymphohistiocytosis.Semantic proximity Read ↗

Genetics and pathophysiology of haemophagocytic lymphohistiocytosis.Semantic proximity Read ↗

Hemophagocytic lymphohistiocytosis (HLH) and related disorders.Semantic proximity Read ↗

Primary and secondary hemophagocytic lymphohistiocytosis: clinical features, pathogenesis and therapy.Semantic proximity Read ↗

Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathologySemantic proximity Read ↗

Advances in understanding the pathogenesis of HLH.Semantic proximity Read ↗

Hemophagocytic LymphohistiocytosisSemantic proximity Read ↗

Hemophagocytic Lymphohistiocytosis in Adolescents and Young Adults: Genetic Predisposition and Secondary Disease.Semantic proximity Read ↗

Genetics of Primary Hemophagocytic Lymphohistiocytosis.Semantic proximity Read ↗

Hemophagocytic Lymphohistiocytosis: When the Immune System Runs AmokSemantic proximity Read ↗

Hemophagocytic lymphohistiocytosis: diagnosis, pathophysiology, treatment, and future perspectives.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.