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Hemophagocytic lymphohistiocytosis: diagnosis, pathophysiology, treatment, and future perspectives.

Annals of medicine - 1 Jan 2006

Verbsky James W, Grossman William J

Abstract excerpt

Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease in which the immune system becomes overactive due to its inability to effectively respond to infections and/or shut down the immune response to such infections. The discovery of genetic defects in the secretory pathway of natural killer (NK) cells and cytotoxic T cells in some patients with this disease has raised important questions of...

Topics

Animals
DNA
Diagnosis, Differential
Humans
Immunity, Cellular
Immunologic Factors
Killer Cells, Natural
Lymphohistiocytosis, Hemophagocytic
Membrane Glycoproteins
Mutation
Perforin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pore Forming Cytotoxic Proteins

Signal Transduction

T-Lymphocyte Subsets

T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 16448985
DOI: 10.1080/07853890500465189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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