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Article

Genetics and pathophysiology of haemophagocytic lymphohistiocytosis.

Acta paediatrica (Oslo, Norway : 1992) - 1 Nov 2021

Meeths Marie, Bryceson Yenan T

Abstract excerpt

Haemophagocytic lymphohistiocytosis (HLH) represents a life-threatening hyperinflammatory syndrome. Familial studies have established autosomal and X-linked recessive causes of HLH, highlighting a pivotal role for lymphocyte cytotoxicity in the control of certain virus infections and immunoregulation. Recently, a more complex etiological framework has emerged, linking HLH predisposition to variants in genes...

Topics

Genetic Predisposition to Disease
Humans
Lymphohistiocytosis, Hemophagocytic
Virus Diseases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34192386
DOI: 10.1111/apa.16013

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