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Article

Repression of an interleukin-4-responsive promoter requires cooperative BCL-6 function.

The Journal of biological chemistry - 1 Apr 2005

Harris Miera B, Mostecki Justin, Rothman Paul B

Abstract excerpt

BCL-6 functions as a potent transcriptional repressor that binds with specificity to DNA elements bearing marked similarity to STAT recognition sequences. Previous studies have demonstrated that BCL-6 and Stat6 can both bind and regulate the Iepsilon promoter that controls immunoglobulin heavy chain class switching to IgE. Examination of BCL-6-/- and BCL-6-/-Stat6-/- mice has demonstrated that BCL-6 is a...

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PMID: 15659391
DOI: 10.1074/jbc.M412649200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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