Article
STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas.
Oncogene - 11 Jan 2007
Walker S R, Nelson E A, Frank D A
Abstract excerpt
Deregulated expression of BCL6 is a pathogenic event in many lymphomas. BCL6 blocks cellular differentiation by repressing transcription of its target genes, and this may promote tumorigenesis. Conversely, the transcription factor signal transducers and activators of transcription (STAT)5 promotes differentiation in many systems. STAT5 upregulates a number of genes repressed by BCL6, raising the possibility that...
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