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Article

Stability of mutant serpin/furin complexes: dependence on pH and regulation at the deacylation step.

Protein science : a publication of the Protein Society - 1 Feb 2005

Dufour Erick K, Désilets Antoine, Longpré Jean-Michel, Leduc Richard

Abstract excerpt

Furin proteolytically cleaves a wide variety of proprotein substrates mainly within the trans-Golgi network (TGN) but also at the cell membrane and in endosomal compartments where pH is more acidic. Incorporation of furin recognition sequences within the reactive site loop (RSL) of alpha(1)-antitrypsin (AT) leads to the production of furin inhibitors. In an attempt to design more stable, potent, and specific...

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PMID: 15659365
DOI: 10.1110/ps.04843305
PMCID: PMC2253415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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