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Article

pH Induced Conformational Transitions in the Transforming Growth Factor β-Induced Protein (TGFβIp) Associated Corneal Dystrophy Mutants.

Scientific reports - 31 Mar 2016

Murugan Elavazhagan, Venkatraman Anandalakshmi, Lei Zhou, Mouvet Victoria, Rui Yi Lim Rayne, Muruganantham Nandhakumar, Goh Eunice, Swee Lim Peh Gary, Beuerman Roger W, Chaurasia Shyam S, Rajamani Lakshminarayanan, Mehta Jodhbir S

Abstract excerpt

Most stromal corneal dystrophies are associated with aggregation and deposition of the mutated transforming growth factor-β induced protein (TGFβIp). The 4(th)_FAS1 domain of TGFβIp harbors ~80% of the mutations that forms amyloidogenic and non-amyloidogenic aggregates. To understand the mechanism of aggregation and the differences between the amyloidogenic and non-amyloidogenic phenotypes, we expressed the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27030015
DOI: 10.1038/srep23836
PMCID: PMC4814907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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