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Article

pH driven fibrillar aggregation of the super-sweet protein Y65R-MNEI: A step-by-step structural analysis.

Biochimica et biophysica acta. General subjects - 1 Apr 2018

Pica Andrea, Leone Serena, Di Girolamo Rocco, Donnarumma Federica, Emendato Alessandro, Rega Michele Fortunato, Merlino Antonello, Picone Delia

Abstract excerpt

BACKGROUND: MNEI and its variant Y65R-MNEI are sweet proteins with potential applications as sweeteners in food industry. Also, they are often used as model systems for folding and aggregation studies. METHODS: X-ray crystallography was used to structurally characterize Y65R-MNEI at five different pHs, while circular dichroism and fluorescence spectroscopy were used to study their thermal and chemical stability....

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PMID: 29288772
DOI: 10.1016/j.bbagen.2017.12.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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