Article

The conformational landscape of a serpin N-terminal subdomain facilitates folding and in-cell quality control

2023-04-26

Abstract excerpt

<h4>ABSTRACT</h4> Many multi-domain proteins including the serpin family of serine protease inhibitors contain non-sequential domains composed of regions that are far apart in sequence. Because proteins are translated vectorially from N-to C-terminus, such domains pose a particular challenge: how to balance the conformational lability necessary to form productive interactions between early and late translated reg...

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Literature Corpus work: 504ccf3f-4262-5cbe-8f12-0a8bd822cca6
DOI: 10.1101/2023.04.24.537978

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