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Article

Telomere‐independent cellular senescence in human fetal cardiomyocytes

10 Dec 2004

Abstract excerpt

Fetal cardiomyocytes have been proposed as a potential source of cell-based therapy for heart failure. This study examined cellular senescence in cultured human fetal ventricular cardiomyocytes (HFCs). HFCs were isolated and identified by immunocytochemistry and RT-PCR. Cells were found to senesce after 20-25 population doublings, as determined by growth arrest, morphological changes and senescence-associated...

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Share to Congenital heart defects research
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PMID: 15659210
DOI: 10.1111/j.1474-9728.2004.00137.x

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