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Article

Evidence that high telomerase activity may induce a senescent-like growth arrest in human fibroblasts.

The Journal of biological chemistry - 28 Feb 2003

Gorbunova Vera, Seluanov Andrei, Pereira-Smith Olivia M

Abstract excerpt

Expression of the catalytic subunit of human telomerase (hTERT), in normal human fibroblasts allows them to escape replicative senescence. However, we have observed that populations of hTERT-immortalized human fibroblasts contain 3-20% cells with a senescent morphology. To determine what causes the appearance of these senescent-like cells, we used flow cytometry to select them from the population and analyzed...

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Identifiers

PMID: 12496279
DOI: 10.1074/jbc.M212944200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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