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Article

Natural merodiploidy involving duplicated rpoB alleles affects secondary metabolism in a producer actinomycete.

Molecular microbiology - 1 Jan 2005

Vigliotta Giovanni, Tredici Salvatore Maurizio, Damiano Fabrizio, Montinaro Maria Rosa, Pulimeno Rita, di Summa Roberta, Massardo Domenica Rita, Gnoni Gabriele V, Alifano Pietro

Abstract excerpt

Actinomadura sp. ATCC 39727 produces the glycopeptide antibiotic A40926, structurally similar to teicoplanin. Production of A40926 is governed by the stringent response at the transcriptional level. In fact, addition of an amino acid pool prevented the transcription of dbv cluster genes involved in the A40926 biosynthesis and the antibiotic production in chemically defined media, and a thiostrepton-resistant...

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PMID: 15659159
DOI: 10.1111/j.1365-2958.2004.04406.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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